Pan-cancer analysis of ABCC1 as a potential prognostic and immunological biomarker

• DOI: 10.1016/j.tranon.2024.101882
• Publication Date: 2024-01-29T17:58:44Z
• Authors: Tiantian Wang; Dean Rao; Chenan Fu; Yiming Luo; Junli Lu; Huifang Liang; Limin Xia; Wenjie Huang
• Keywords: 0303 health sciences; 03 medical and health sciences; Hepatocellular carcinoma; Pan-cancer analysis; ABCC1; Tumor-infiltrating macrophages; Immunity; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Prognosis; RC254-282; Original Research

ABCC1 belongs to the ATP-binding cassette (ABC) superfamily, which encompasses a total of 48 constituent members. ABCC1 has been shown to be associated with the growth, progression, and drug resistance of various types of cancer. However, the impact of ABCC1 on cancer immune infiltration and pan-cancer prognosis has been rarely studied. Our comprehensive pan-cancer analysis unveiled elevated ABCC1 expression across various cancers. ABCC1 overexpression consistently predicted unfavorable outcomes based on TCGA data. Moreover, ABCC1 expression exhibited intricate associations with diverse immune-related genes and demonstrated a close correlation with immune scores across multiple tumor types. Analysis of scRNA-seq data from the GEO database revealed that the expression of ABCC1 in hepatocellular carcinoma (HCC) cells is significant positively correlated with macrophage infiltration. Furthermore, various in vitro and in vivo experiments substantiated the role of ABCC1 in promoting the progression of HCC, along with increased macrophage recruitment. Based on the results, we propose ABCC1 as a potentially valuable prognostic indicator and a prospective target for immune-based cancer therapies.