CCR7 affects the tumor microenvironment by regulating the activation of naïve CD8+ T cells to promote the proliferation of oral squamous cell carcinoma

• DOI: 10.1016/j.tranon.2024.101924
• Publication Date: 2024-03-02T00:37:41Z
• Authors: Cong Yan; Weidong Du; Keith L. Kirkwood; Yao Wang; Wanhang Zhou; Zhenning Li; Yuan Tian; Shanfeng Lin; Li Zheng; Maged Ali Al-Aroomi; Jiaxing Gao; Sheng Jiang; Changfu Sun; Fayu Liu
• Keywords: 0303 health sciences; 03 medical and health sciences; Tumor microenvironment; Activation; Oral squamous cancer carcinoma; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Naïve CD8+ T cell; RC254-282; CCR7; Original Research

Head and neck cancer is the sixth most common malignancy worldwide, oral squamous cell carcinoma (OSCC) head cancer, being one of leading causes morbidity mortality worldwide. CC Chemokine receptor 7(CCR7) a multifunctional G protein-coupled trans-membrane chemokine that affects immune chemotaxis, migration, progression through its interaction with ligands C-C motif ligand 19(CCL19) 21(CCL21). Numerous studies have demonstrated involvement CCR7 in malignant variety cancers, reflecting pro-cancer properties CCR7. The Cancer Genome Atlas data suggests has elevated expression cancer. Specifically, tumor microenvironment (TME) may regulate ability some cells to engage anti-tumor responses. Since CD8+ T become key immunotherapeutic target, role antitumor response naïve TME not been thoroughly investigated. A knockout mouse model was constructed, mechanism ccr7 on regulation by verified under guidance single-cell RNA sequencing combined vivo animal experiments vitro experiments. knocked out impaired growth altered profiles, revealing importance this protein OSCC. Inhibition enhances activation, proliferation, function, suggesting potential as therapeutic target.