Hsa_Circ_0008035 drives immune evasion of gastric cancer via promoting EXT1-mediated nuclear translocation of PKM2

• DOI: 10.1016/j.tranon.2024.102004
• Publication Date: 2024-07-24T07:08:27Z
• Authors: Rongqi Jiang; Ping Li; Enqing Meng; Xu Cheng; Xinyi Wu; Hao Wu
• Keywords: Evasion (ethics); Immune escape

Circular RNAs (circRNAs) have been reported to be associated with the malignant phenotypes of cancer. However, role and underlying mechanism hsa_Circ_0008035 in colorectal cancer (CRC) remains unclear. In this study, we elucidated pivotal hsa_circ_0008035 gastric progression immune evasion. Elevated levels patient serum correlated positively disease advancement, including tumor stages lymph node metastasis. Functional analyses revealed a negative association between CD8+ T cell number function. Mechanistically, encoded novel protein EXT1-219aa, suppressing EXT1 phosphorylation expression. Additionally, regulated pyruvate metabolism by influencing nucleus localization PKM2. The identified EXT1/PKM2 axis further underscored intricate regulatory mechanisms orchestrated cancer, offering potential diagnostic therapeutic implications ongoing pursuit targeted therapies for patients.