Inhibition of STAT3: A promising approach to enhancing the efficacy of chemotherapy in medulloblastoma

• DOI: 10.1016/j.tranon.2024.102023
• Publication Date: 2024-06-08T12:06:23Z
• Authors: Sachindra Kumar; Dube Aakash Arwind; Harish Kumar B; Samyak Pandey; Raksha Nayak; Megh Pravin Vitha...; Nitesh Kumar; K Sreedhara Ranga...
• Keywords: Targeted therapy; 0303 health sciences; 03 medical and health sciences; STAT3 inhibitors; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; Review Article; Chemotherapy resistance; RC254-282; Medulloblastoma; Cancer

Medulloblastoma is a type of brain cancer that primarily affects children. While chemotherapy has been shown to be effective in treating medulloblastoma, the development resistance remains challenge. One potential therapeutic approach selectively inhibit inducible transcription factor called STAT3, which known play crucial role survival and growth tumor cells. The activation STAT3 linked progression various cancers, including medulloblastoma. Inhibition sensitize medulloblastoma cells chemotherapy, leading improved treatment outcomes. Different approaches inhibition have developed, small-molecule inhibitors RNA interference. Preclinical studies efficacy clinical trials are currently ongoing evaluate their safety effectiveness patients with solid tumors, In addition, researchers also exploring ways optimize use combination identify biomarkers can predict will help develop personalized strategies. This review highlights selective as novel for suggests further research into could lead outcomes aggressive cancer.