Combined use of sirolimus and voriconazole in renal transplantation: A report of two cases

• DOI: 10.1016/j.transproceed.2004.09.043
• Publication Date: 2004-12-28T23:59:44Z
• Authors: A.S. Mathis; N.K. Shah; G.S. Friedman
• Keywords: Sirolimus; Tolerability; Trough level; Trough Concentration

Voriconazole is currently contraindicated for use with sirolimus. We report our experience with voriconazole/sirolimus in two renal transplant recipients. To our knowledge, this is the first experience with voriconazole/sirolimus. An interaction requiring a 75% to 87.5% sirolimus dose reduction was noted, but goal trough levels and clinical tolerability were achieved.