Use of Extended Right Grafts From In Situ Split Livers in Adult Liver Transplantation: A Comparison With Whole-Liver Transplants

• DOI: 10.1016/j.transproceed.2005.01.037
• Publication Date: 2005-04-21T11:40:57Z
• Authors: M. Spada; M. Cescon; A. Aluffi; M. Zambelli; M. Guizzetti; A. Lucianetti; D. Pinelli; M. Strazzabosco; B. Gridelli; M. Colledan
• Keywords: Adult; Male; Reoperation; Gastroenterology; Hepatology; Surgery; Transplantation;; 03 medical and health sciences; 0302 clinical medicine; Liver Function Tests; Hepatectomy; Humans; Child; Aged; Retrospective Studies; Health Care Rationing; Liver Diseases; Hemodynamics; LIVER TRANSPLANTATION; Organ Size; Middle Aged; Liver Transplantation; 3. Good health; Treatment Outcome; Child, Preschool; Tissue and Organ Harvesting; Female; split liver; liver transplant

We report our experience of in situ split-liver transplantation (SLT) for adult patients and compare the results with those achieved with whole-liver transplantation (WLT).From November 1997 to December 2003, 109 liver transplantation were performed in 104 adult patients including 90 WLT (83%) and 19 SLT (17%) grafts. Fifteen extended right grafts (ERG, segments I + IV to VIII) were obtained with in situ split-liver procedures, generating also left lateral segment grafts, which were transplanted at our institution or elsewhere. Four left lobe (LL, segments I to IV) and right lobe (segments V to VIII) grafts were obtained by a modified in situ procedure for adult recipients. UNOS status, percentage of primary or secondary transplantation, and underlying liver disease were similar among patients receiving whole versus split grafts. Donors were older in whole than ERG cohorts (53 vs 26 years, P < .001). Procurement parameters and intraoperative profiles of transplant procedure were comparable among the groups.Median follow-up was 18 months (range: 1 to 73). Four patients with whole (4%) and no patient with ERG underwent retransplantation (P = NS). One- and 3-year patient survivals were 86% and 79% with WLT versus 93% and 93% with ERG (P = NS). One- and 3-year graft survivals were 84% and 75% with WLT versus 93%, and 93% with ERG (P = NS). Incidence of vascular complications was 8% with WLT, 13% with ERG (P = NS). The incidence of biliary complications was 13% in WLT, 27% in ERG (P = NS).The use of ERG from in situ split livers for adult transplantation allowed us to obtain results comparable or even better than those obtained with WLT. Split-liver transplantation is an effective, safe mechanism to expand the cadaveric donor pool.