Ficus carica polysaccharide extraction via ultrasound-assisted technique: Structure characterization, antioxidant, hypoglycemic and immunomodulatory activities

• DOI: 10.1016/j.ultsonch.2023.106680
• Publication Date: 2023-11-08T20:26:46Z
• Authors: Weilan Wang; Xiaoying Liu; Lixue Wang; Guirong Song; Wei Jiang; Lihong Mu; Jinyao Li
• Keywords: Carica; Ficus

In this research, the ultrasound-assisted extraction (UAE) conditions of water-soluble polysaccharide (FCPS) from Ficus carica fruits were optimized using response surface methodology. The optimal FCPS yield was 7.97 % achieved by conducting four times at a solid–liquid ratio 1:20 (g/mL) and an ultrasound temperature 70 °C. Then, structure, antioxidant properties, hypoglycemic effects, immunomodulatory activities evaluated. characterized as irregular, rough-surfaced, flaky materials consisting pyran-type polysaccharides with α- β-glycosidic linkages, composed multiple monosaccharides only one homogeneous concentrated component (FCPS1) molecular weight 4.224 × 104 Da. results suggested exhibited remarkable activity in vitro, evidenced improved cell viability reduced reactive oxygen species (ROS) levels. Meanwhile, effectively liver-related insulin resistance promoting glucose consumption hepatocytes activated immune through activation murine bone marrow-derived dendritic cells (DCs) upregulation interleukin 6 (IL6) 12 (IL-12) expression. findings demonstrate efficacy UAE technique isolating biological functionality could potentially serve beneficial organic source functional food, carrying important implications for future studies.