Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines

• DOI: 10.1016/j.vaccine.2003.11.007
• Publication Date: 2003-12-02T13:24:17Z
• Authors: Xuan-Yi Wang; Zhiyi Xu; Xing Yao; Meiying Tian; Liangdi Zhou; Lifang He; Yumei Wen
• Keywords: Hepatitis A vaccine; Inactivated vaccine; Attenuated vaccine; Subclass

The immunogenicity of a live attenuated HAV vaccine and an inactivated HAV vaccine was compared. Altogether 117 children were vaccinated with either the inactivated or the live attenuated vaccine. Children were bled at months 1, 6, 7, 12 and 24, and the anti-HAV total IgG antibody and IgG subclass profile were assessed. In both vaccinated groups, the geometric mean titer (GMT) of anti-HAV peaked 7 months after the initial dose and declined during the following months. The IgG subclass profiles in both vaccinated groups were highly restricted to IgG1 and IgG3. Both vaccines have been shown highly effective in preventing viral hepatitis A in former studies.