ADE and dengue vaccination

• DOI: 10.1016/j.vaccine.2017.06.004
• Publication Date: 2017-06-14T04:30:52Z
• Authors: Ruth Aralí Martín...; Gabriel Carrasquila; Expedito Luna; José Ramos-Castañeda
• Keywords: Dengue; 0303 health sciences; 03 medical and health sciences; Models, Statistical; Vaccination; Humans; Dengue Vaccines; Dengue Virus; Antibody-Dependent Enhancement; 3. Good health

The vaccine against Dengue virus (DENV), Dengvaxia® (CYD), produced by Sanofi-Pasteur, has been registered by several national regulatory agencies; nevertheless, the performance and security of this vaccine have been challenged in a series of recent papers. In this work, we intend to contribute to the debate by analyzing the concept of an enhancing vaccine, presenting objections to the epidemiological model base of the concept and, likewise, presenting data that contradict that concept.