Pathogenic analysis of coxsackievirus A10 in rhesus macaques

• DOI: 10.1016/j.virs.2022.06.007
• Publication Date: 2022-06-28T20:07:01Z
• Authors: Suqin Duan; Fengmei Yang; Yanyan Li; Yuan Zhao; Li Shi; Meng Qin; Quan Liu; Weihua Jin; Junbin Wang; Lixiong Chen; Wei Zhang; Yongjie Li; Ying Zhang; Jingjing Zhang; Shaohui Ma; Zhanlong He; Qihan Li
• Keywords: Viremia; Viral Shedding; Coxsackievirus; Pathogenesis; Enterovirus 71

Coxsackievirus A10 (CV-A10) is one of the etiological agents associated with hand, foot and mouth disease (HFMD) also causes a variety illnesses in humans, including pneumonia, myocarditis. Different people, particularly young children, may have different immunological responses to infection. Current CV-A10 infection animal models provide only rudimentary understanding pathogenesis effects this virus. The characteristics infection, replication, shedding humans remain unknown. In study, rhesus macaques were infected by via respiratory or digestive route mimic HFMD humans. clinical symptoms, viral shedding, inflammatory response pathologic changes investigated acute (1-11 day post infection) recovery period (12-180 infection). All during showed obvious viremia symptoms which comparable those observed Substantial pathological damages multi-organs, lung, heart, liver, kidney. During period, all displayed signs, normalization serum cytokines, increased neutralizing antibodies, whereas factors caused some animals develop severe hyperglycemia period. addition, there no significant differences between tract animals. Overall, data presented suggest that first non-human primate model for investigating pathophysiology assessing development potential human therapies.