Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

• DOI: 10.1016/j.virs.2022.12.008
• Publication Date: 2023-01-02T06:51:24Z
• Authors: Pei Yu; Zijian Liu; Zhuoqi Zhu; Jiaqing Yang; Min Deng; Mingxiao Chen; Changchun Lai; Weiya Kong; Shilong Xiong; Li Wan; Weikang Mai; Lu Chen; Yu Lei; Shahzad Akbar Khan; Jianfeng Ruan; An Kang; Xuguang Guo; Qiang Zhou; Wenrui Li; Zheng Chen; Yuemei Liang; Pingchao Li; Lei Zhang; Tianxing Ji
• Keywords: Heterologous; Booster (rocketry)

Homologous booster, heterologous and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against variants. Questions concerning about memory B cells (MBCs) T variants, features of long-term immunity, after booster OBI, needs to be explored. Here, comparative analysis demonstrate antibody cell ancestral strain, Delta in infected patients (OBIPs) are comparable that Ad5-nCoV boosted healthy volunteers (HVs), higher than inactivated vaccine (InV) HVs. However, was highest OBIPs, followed by InV OBIPs HVs have classical MBCs activated MBCs, lower naïve atypical relative both Collectively, these data indicate elicit SARS-CoV-2 especially homologous booster.