Sulforaphane effectively inhibits HBV by altering Treg/Th17 immune balance and the MIF-macrophages polarizing axis in vitro and in vivo

• DOI: 10.1016/j.virusres.2024.199316
• Publication Date: 2024-01-13T23:51:50Z
• Authors: Ruqing Xu; Yue Wu; Xia Xiang; Xiaoqin Lv; Miao He; Chang Xu; Guoqi Lai; Tingxiu Xiang
• Keywords: cccDNA; HBeAg; HBcAg; Sulforaphane; Hepatitis B

Hepatitis B virus (HBV) infection is a major public health problem. After HBV infection, viral antigens shift the immune balance in favor of escape. Sulforaphane (SFN) traditional Chinese medicine.It regulates multi-biological activities, including anti-inflammation, anticancer, and antiviral. However, few studies reported that SFN can inhibit before.