MRTFA overexpression promotes conversion of human coronary artery smooth muscle cells into lipid-laden foam cells

• DOI: 10.1016/j.vph.2021.106837
• Publication Date: 2021-01-29T06:35:11Z
• Authors: Azra Alajbegovic; Johan Holmberg; Fatima Daoud; Catarina Rippe; Gabriella Kalliok...; Mari Ekman; Sébastien Daudi; Sigurdur Ragnarsson; Karl Swärd; Sebastian Albinsson
• Keywords: Foam cell; Lipid droplet; Pinocytosis

Smooth muscle cells contribute significantly to lipid-laden foam in atherosclerotic plaques. However, the underlying mechanisms transforming smooth into are poorly understood. The purpose of this study was gain insight molecular regulating cell formation. Using human coronary artery we found that transcriptional co-activator MRTFA promotes lipid accumulation via several mechanisms, including direct control LDL receptor, enhanced fluid-phase pinocytosis and reduced efflux. Inhibition MRTF activity with CCG1423 CCG203971 accumulation. Furthermore, demonstrate expression vascular remodeling vessels. This demonstrates a novel role for as an important regulator homeostasis cells. Thus, could potentially be new therapeutic target inhibition