Dynamics of AMPA receptors regulate epileptogenesis in patients with epilepsy

• DOI: 10.1016/j.xcrm.2023.101020
• Publication Date: 2023-04-19T14:29:08Z
• Authors: Tsuyoshi Eiro; Tomoyuki Miyazaki; Mai Hatano; Waki Nakajima; Tetsu Arisawa; Yuuki Takada; Kimito Kimura; Akane Sano; Kotaro Nakano; Takahiro Mihara; Yutaro Takayama; Naoki Ikegaya; Masaki Iwasaki; Akitoyo Hishimoto; Yoshihiro Noda; Takahiro Miyazaki; Hiroyuki Uchida; Hideaki Tani; Nobuhiro Nagai; Teruki Koizumi; Shinichiro Nakajima; Masaru Mimura; Nozomu Matsuda; Kazuaki Kanai; Kazuhiro Takahashi; Hiroshi Ito; Yoji Hirano; Yuichi Kimura; Riki Matsumoto; Akio Ikeda; Takuya Takahashi
• Keywords: Neurons; Epilepsy; Seizures; Humans; Receptors, AMPA; Article; 3. Good health

The excitatory glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors (AMPARs) contribute to epileptogenesis. Thirty patients with epilepsy and 31 healthy controls are scanned using positron emission tomography our recently developed radiotracer for AMPARs, [11C]K-2, which measures the density of cell-surface AMPARs. In focal-onset seizures, an increase in AMPAR trafficking augments amplitude abnormal gamma activity detected by electroencephalography. contrast, generalized-onset seizures exhibit a decrease AMPARs coupled increased activity. Patients had reduced levels compared controls, larger areas cortex those seizures. Thus, epileptic brain function can be regulated enhanced due Hebbian plasticity simultaneous neuronal firing compensational downregulation synaptic scaling.