Vascular invasion predicts the subgroup of lung adenocarcinomas ≤2.0 cm at risk of poor outcome treated by wedge resection compared to lobectomy

• DOI: 10.1016/j.xjon.2023.11.003
• Publication Date: 2023-11-13T07:16:55Z
• Authors: Lina Ma; Travis B. Sullivan; Kimberly M. Riege...; Ilyas Yambayev; Qing Zhao; Sara E. Higgins; Osman H. Yilmaz; Lila Sultan; Elliot L. Servais; Kei Suzuki; Eric J. Burks
• Keywords: Wedge resection; Resection margin

Recent randomized control trials (JCOG0802 and CALGB140503) have shown sublobar resection to be noninferior lobectomy for non-small cell lung cancer (NSCLC) ≤2.0 cm. We previously proposed histologic criteria stratifying adenocarcinoma into indolent low malignant potential (LMP) aggressive angioinvasive adenocarcinomas, resulting in better prognostication than provided by World Health Organization grade. Here we determine whether pathologic classification is reproducible subsets of adenocarcinomas predict worse outcomes when treated wedge compared lobectomy.