An angiotensin system inhibitor (losartan) potentiates antitumor efficacy of cisplatin in a murine model of non–small cell lung cancer

• DOI: 10.1016/j.xjon.2024.01.014
• Publication Date: 2024-02-01T22:21:13Z
• Authors: Hexiao Tang; Eric Abston; Mozhdeh Sojoodi; Yongtao Wang; Derek J. Erstad; Zenan Lin; Bryan C. Fuchs; Kenneth K. Tanabe; Michael Lanuti

e -p r o f mesenchymal to epithelial phenotype and reduced tumor size following combination losartan cisplatin treatment.Conclusions: Combination treatment attenuates the EMT pathway enhances cytotoxic effect of chemotherapy with in vitro vivo models NSCLC.This study suggests an important role for ASI therapy lung cancer.