Quantitative Volumetric Analysis of Retinal Ischemia with an Oxygen Diffusion Model and OCT Angiography

• DOI: 10.1016/j.xops.2024.100579
• Publication Date: 2024-07-19T02:56:01Z
• Authors: Pengxiao Zang; Tristan T. Hormel; Thomas S. Hwang; Yali Jia
• Keywords: Ophthalmology; 03 medical and health sciences; 0302 clinical medicine; Retinal ischemia; Diabetic retinopathy; OCT angiography; Original Article; RE1-994; Oxygen distribution

PurposeRetinal ischemia is a major feature of diabetic retinopathy (DR). Traditional nonperfused areas measured by OCT angiography (OCTA) measure blood supply but not ischemia. We propose novel 3-dimensional (3D) quantitative method to derive measurements from OCTA data.DesignCross-sectional study.ParticipantsWe acquired 223 macular volumes 33 healthy eyes, eyes without retinopathy, 7 with nonreferable DR, 17 referable nonvision-threatening and 133 vision-threatening DR.MethodsEach eye was scanned using spectral-domain system (Avanti RTVue-XR, Visionix/Optovue, Inc) 1.6-mm scan depth in 3 × 3-mm region (640 304 voxels) centered on the fovea. For each volume, custom algorithm removed flow projection artifacts. then enhanced, binarized, skeletonized vasculature volume generated 3D oxygen tension map zero-order kinetics diffusion model. Each scaled average retina thickness controls after foveal registration flattening Bruch's membrane. Finally, we extracted maps comparison reference established scans same processing. To assess ability grade DR severity, constructed receiver operating characteristic curves for diagnosing diabetes, DR.Main Outcome MeasuresSpearman correlation coefficient area under curve (AUC) were used quantify DR.ResultsThe showed that ischemic tissues at or near pathologically areas, normally nonvascular tissue, such as avascular zone. found multiple metrics, including inferred 3D-oxygen tension, index, ratio, strongly correlated severity. The AUCs index 0.94 0.89 0.88 0.85 DR.ConclusionsA infer can identify tissue are more specific pathologic changes DR.Financial DisclosuresProprietary commercial disclosure may be Footnotes Disclosures end this article.