Emx2 and early hair cell development in the mouse inner ear

• DOI: 10.1016/j.ydbio.2010.02.004
• Publication Date: 2010-02-11T06:44:46Z
• Authors: Matthew Holley; Charlotte Rhodes; Adam Kneebone; Michel K. Herde; Michelle Fleming; Karen P. Steel
• Keywords: EMX2; Polarity (international relations); Cell polarity

Emx2 is a homeodomain protein that plays critical role in inner ear development. Homozygous null mice die at birth with range of defects the CNS, renal system and skeleton. The cochlea shorter than normal about 60% fewer auditory hair cells. It appears to lack outer cells some supporting are either absent or fail differentiate. Many differentiate pairs although their bundles develop normally planar cell polarity compromised. Measurements suggest classic molecules not directly influenced by compromised developmental sensory precursor population epithelial cues for alignment. Planar vestibular epithelia reversal across striola both utricular saccular maculae. In contrast, cochlear disorganized. expression domain Bmp4 expanded Fgfr1 Prox1 expressed epithelium mice. We conclude regulates early events balance proliferation differentiation population.