The developmental origin of heart size and shape differences in Astyanax mexicanus populations

• DOI: 10.1016/j.ydbio.2018.06.009
• Publication Date: 2018-06-22T17:50:39Z
• Authors: Jocelyn L.Y. Tang; Yu Guo; William T. Stockdale; Kerisha Rana; Abigail C. Killen; Mathilda T.M. Mom...; Yoshiyuki Yamamoto
• Keywords: Morphology; Heart development; Epigeal

Regulation of heart size and shape is one the least understood processes in developmental biology. We have for first time analysed hearts Astyanax mexicanus identified several differences morphology between surface (epigean morph) cave-dwelling (troglomorph) morphs. Examination adult revealed that troglomorph possesses a smaller with rounder ventricle comparison to epigean morph. The appear arise early development, as 24 h post-fertilisation (hpf), while begin at 2 days post-fertilisation. first-generation cross river-dwelling morph shows uncoupling different phenotypes observed parental populations indicates cardiac become embedded genome during evolution. are accompanied by functional changes two morphs, exhibiting slower rate than identification morphological A. could allow us gain more insight into how such parameters regulated potential relevance pathologies humans.