fMRI BOLD and MEG theta power reflect complementary aspects of activity during lexicosemantic decision in adolescents with ASD

• DOI: 10.1016/j.ynirp.2022.100134
• Publication Date: 2022-10-15T04:47:58Z
• Authors: M. Wilkinson; R.J. Jao Keehn; A.C. Linke; Y. You; Y. Gao; K. Alemu; A. Correas; B.Q. Rosen; J.S. Kohli; L. Wagner; A. Sridhar; K. Marinkovic; R.-A. Müller
• Keywords: Magnetoencephalography; Gyrus

Neuroimaging studies of autism spectrum disorder (ASD) have been predominantly unimodal. While many fMRI reported atypical activity patterns for diverse tasks, the MEG literature in ASD remains comparatively small. Our group recently atypically increased event-related theta power individuals with during lexicosemantic processing. The current multimodal study examined relationship between BOLD signal and anatomically-constrained (aMEG) power. Thirty-three adolescents 23 typically developing (TD) peers took part both scans, which they distinguished standard words (SW), animal (AW), pseudowords (PW). Regions-of-interest (ROIs) were derived based on task effects detected aMEG extracted each ROI word condition. Compared to TD participants, was found across several time windows regions including left fusiform inferior frontal, as well right angular anterior cingulate gyri, whereas significantly only gyrus. No significant correlations observed Findings suggest that common interpretation increases ‘activation’ require careful differentiation, these reflect largely distinct aspects regional brain activity. Some differences dynamic neural processing are likely relevant lexical may be obscured by hemodynamic source low temporal resolution fMRI.