Reward sensitivity modulates the brain reward pathway in stress resilience via the inherent neuroendocrine system

• DOI: 10.1016/j.ynstr.2022.100485
• Publication Date: 2022-09-07T17:13:44Z
• Authors: Weiyu Hu; Xiaolin Zhao; Yadong Liu; Yipeng Ren; Zhenni Wei; Zihan Tang; Yun Tian; Yadong Sun; Juan Yang
• Keywords: Reward system; Putamen; Allostasis; Brain stimulation reward; Stressor

In the previous 10 years, researchers have suggested a critical role for brain reward system in stress resilience. However, no study has provided an empirical link between activity mesostriatal regions during and recovery of cortisol response. Moreover, although sensitivity as trait been demonstrated to promote resilience, it remains unclear whether modulates resilience how this effect is achieved by inherent neuroendocrine system. To investigate these uncertainties, 70 young adults were recruited participate ScanSTRESS task, their imaging data saliva samples (for assay) collected task. addition, we assessed sensitivity, awakening response, intrinsic functional connectivity all participants. We found that left putamen activation exposure positively predicted recovery. was linked with putamen, relationship serially mediated response right hippocampus-left inferior frontal gyrus connectivity. These findings suggest pathways through interplay diurnal network hippocampus-prefrontal circuitry. Summarily, current built model highlight dynamic multifaceted interaction pertinent allostatic factors reward-resilience pathway uncovered new insight into function stress.