The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model

• DOI: 10.1016/j.ynstr.2023.100570
• Publication Date: 2023-09-18T16:37:50Z
• Authors: Miseon Kang; Jun-mo Chung; Jihyun Noh; Jeongyeon Kim
• Keywords: Vulnerability; Mineralocorticoid

The lateral habenula (LHb) plays a pivotal role in regulating emotional responses during stress reactions, and its hyperactivity has been associated with depression. Recently it demonstrated that chronic early-life results individual differences vulnerability among rodents. However, how synaptic function the LHb varies between susceptibility resilience to early life remains elusive. In this study, we used maternal separation model assign animals different vulnerabilities into groups investigated LHb. Our findings indicate long-term depression (LTD) was impaired extra-synaptic LTD enhanced of susceptible group. To mimic alteration situations, when administered corticosterone, hormone, intervention appeared impair control group, through activation mineralocorticoid receptors (MR). Indeed, there an up-regulation MR mRNA observed Following both NR2A NR2B subunits These indicated NMDA are critically engaged susceptibilities stress. Furthermore, our propose potential therapeutic targets for alleviating stress-related symptoms.