Genetic analysis of deciduous tooth size in Australian twins

Male Twins 590 Mandible Environment Monozygotic 03 medical and health sciences Sex Factors 0302 clinical medicine Genetic Models Dizygotic Maxilla Twins, Dizygotic Humans Odontometry Tooth, Deciduous Preschool Child Tooth Crown Analysis of Variance Chi-Square Distribution Models, Genetic Australia Deciduous Twins, Monozygotic Models, Dental Child, Preschool Dental Female Tooth
DOI: 10.1016/s0003-9969(00)00066-2 Publication Date: 2002-07-25T10:22:55Z
ABSTRACT
Investigations of permanent dental crown size in twins and family groups indicate a high degree of transmissible control, but little is known about the relative contributions of genetic and environmental factors to variation in size of the deciduous (primary) teeth. Here, maximum mesiodistal and buccolingual crown dimensions of maxillary and mandibular primary teeth were measured from dental models of 602 individuals, including 99 monozygous (MZ) twin pairs, 81 dizygous (DZ) same-sex pairs, 41 DZ opposite-sex pairs, and 160 singletons. Data were subjected to univariate genetic analysis with the structural-equation-modelling package, Mx using the normal assumptions of the twin model. A model incorporating additive genetic (A) and unique environmental (E) variation was found to be the most parsimonious for all tooth-size variables. Estimates of heritability for deciduous crown size ranged from 0.62 to 0.91. This study shows that variation in deciduous crown size has a strong genetic component, similar to that observed in the permanent dentition. Further studies are required to determine whether the underlying genetic mechanisms are the same for both deciduous and permanent teeth.
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