Spatial memory deficits in segmental trisomic Ts65Dn mice

• DOI: 10.1016/s0166-4328(97)81111-4
• Publication Date: 2002-07-25T11:22:27Z
• Authors: Gregory E. Demas; Randy J. Nelson; Bruce K. Krueger; Paul J. Yarowsky
• Keywords: Spontaneous alternation

Spatial memory was assessed in the segmental trisomic 16 mouse (Ts65Dn), a potential model for Down syndrome (DS), using 12-arm radial maze (RAM). Ts65Dn mice have portion of chromosome syntenic to distal end human 21 triplicated. On each 8 daily trials RAM, made fewer correct choices than control and performed at or near chance levels, indicating deficit spatial working memory. 9 10, as well on initial 12 choices, but required greater number complete RAM. The improved performance 10 lost when animals were retested after 50-day retention period, suggesting that long-term is also defective. These results are not likely explained by differences either response bias perceptual discrimination. displayed comparable levels spontaneous alternation T-maze, demonstrating simple impaired. In elevated plus maze, did display higher anxiety which could affect their fact, visited open arms more frequently spent time mice. Taken together, these provide evidence short- deficits