Analysis of radiation dose-response curve obtained with cytokinesis block micronucleus assay

• DOI: 10.1016/s0969-8051(97)80008-x
• Publication Date: 2011-09-20T08:07:31Z
• Authors: Solomon F.D. Paul; P. Venkatachalam; R.K. Jeevanram
• Keywords: Micronucleus Tests; Gamma Rays; Humans; Dose-Response Relationship, Radiation

The frequency of micronuclei and acentrics obtained with different doses of 60Co gamma radiation was examined. When compared to acentric frequency the micronuclei frequency was found to be higher at about 115% for doses below 1 Gy. However, it dropped to about 65% as the dose was increased to 4 Gy. This paper discusses the causes for the reduced frequency of micronuclei at higher doses by taking into account the possibility of their being masked from view by the daughter nuclei in the binucleated cell.