Supplementation of iron alone and combined with vitamins improves haematological status, erythrocyte membrane fluidity and oxidative stress in anaemic pregnant women

• DOI: 10.1017/s000711451000259x
• Publication Date: 2010-07-09T05:26:24Z
• Authors: Ai Guo Ma; Evert G. Schouten; Yong Ye Sun; Fang Yang; Xiu Xia Han; Feng Zhi Zhang; Dian Chen Jiang; Frans J. Kok
• Keywords: Malondialdehyde

Pregnancy is a condition exhibiting increased susceptibility to oxidative stress, and Fe plays central role in generating harmful oxygen species. The objective of the present study investigate changes haematological status, stress erythrocyte membrane fluidity anaemic pregnant women after supplementation with without combined vitamins. was 2 months double-blind, randomised trial. Pregnant ( n 164) were allocated four groups: group C placebo control group; I supplemented daily 60 mg (ferrous sulphate) daily; IF plus 400 μg folic acid; IM retinol 1 riboflavin, respectively. After 2-month trial, Hb significantly by 15·8, 17·3 21·8 g/l, ferritin 2·8, 3·6 11·0 μg/l, I, groups compared placebo. Polarisation (ρ) microviscosity (η) decreased other placebo, indicating an increase fluidity. Significant decreases ρ η values 0·033 0·959 for 0·037 1·074 0·064 1·865 IM, In addition, significant increases glutathione peroxidase activities malondialdehyde shown all treated groups, as well plasma urine riboflavin IM. findings show that particularly combination vitamins could improve status