Dietary supplementation with proline confers a positive effect in both porcine circovirus-infected pregnant and non-pregnant mice

• DOI: 10.1017/s0007114513000652
• Publication Date: 2013-03-18T13:56:19Z
• Authors: Wenkai Ren; Miaomiao Wu; Wei Luo; Ruilin Huang; Yulong Yin; Yinghui Li; Teijun Li; Xinglong yu
• Keywords: Circovirus

Porcine circovirus type 2 (PCV2) is associated with various diseases that impose a significant economic burden on the swine industry. We hypothesised nutritional supplementation proline to enhance immune response might be useful prophylactic measure against PCV2 infection. To test this hypothesis, in present study, we measured clinical data, including blood parameters, serum cytokine profile, virus load organs and serum, microscopic lesions lung, liver spleen, both PCV2-infected pregnant non-pregnant mice. Dietary had no effect (P>0·05) abortion rates mice, although numerically lower rate (22·2 v. 44·4%) was observed compared control. significantly increased C-reactive protein levels (P= 0·03) TNF-α 0·01), leucocytes (P< 0·05), lymphocytes 0·05) neutrophilic granulocytes Meanwhile, dietary decreased lung. Furthermore, mice group showed 0·01) decrease lesion scores spleen those alanine group. Collectively, confers functional role