Xylo-oligosaccharides alone or in synbiotic combination withBifidobacterium animalissubsp.lactisinduce bifidogenesis and modulate markers of immune function in healthy adults: a double-blind, placebo-controlled, randomised, factorial cross-over study

• DOI: 10.1017/s0007114513004261
• Publication Date: 2014-03-25T02:18:02Z
• Authors: Caroline E. Childs; Henna Röytiö; Esa Alhoniemi; Agnes A. Fekete; Sofia D. Forssten; Natasa Hudjec; Ying Ni Lim; Cara J. Steger; Parveen Yaqoob; Kieran M. Tuohy; Robert A. Rastall; Arthur C. Ouwehand; Glenn R. Gibson
• Keywords: Bifidobacterium animalis; Prebiotic; Synbiotics; Bifidobacterium breve; Flatulence; Fructooligosaccharide

Prebiotics, probiotics and synbiotics are dietary ingredients with the potential to influence health mucosal systemic immune function by altering composition of gut microbiota. In present study, a candidate prebiotic (xylo-oligosaccharide, XOS, 8 g/d), probiotic ( Bifidobacterium animalis subsp. lactis Bi-07, 10 9 colony-forming units (CFU)/d) or synbiotic (8 g XOS+10 CFU Bi-07/d) was given healthy adults (25–65 years) for 21 d. The aim identify effect supplements on bowel habits, self-reported mood, microbiota, blood lipid concentrations function. XOS supplementation increased mean movements per d P = 0·009), but did not alter symptoms bloating, abdominal pain flatulence incidence any reported adverse events compared maltodextrin supplementation. significantly participant-reported vitality 0·003) happiness 0·034). Lowest use analgesics observed during XOS+Bi-07 period 0·004). faecal bifidobacterial counts 0·008) fasting plasma HDL 0·005). Bi-07 B. content 0·007), lowered lipopolysaccharide-stimulated IL-4 secretion in whole-blood cultures 0·035) salivary IgA 0·040) IL-6 0·009). resulted lower expression CD16/56 natural killer T cells 0·027) IL-10 0·049), while reduced CD19 B (XOS × study demonstrates that induce bifidogenesis, improve aspects profile modulate markers adults. provision as may confer further benefits due discrete effects microbiota