Prevalence and determinants of vitamin D deficiency in the third trimester of pregnancy: a multicentre study in Switzerland

• DOI: 10.1017/s0007114517003634
• Publication Date: 2018-01-10T10:17:30Z
• Authors: Jean-Philippe Kri...; Sophie Cabaset; Claudia Canonica; Ladina Christoffel; Aline Richard; Therese Schröder; Begoña Lipp von W...; Sabine Rohrmann; Katharina Quack L...
• Keywords: Quartile; Cord blood

Vitamin D deficiency during pregnancy is associated with negative health consequences for mothers and their infants. Data on the vitamin status of pregnant women in Switzerland are scarce. A three-centre study was conducted obstetric departments Zurich, Bellinzona Samedan (Switzerland) to investigate prevalence determinants (serum 25-hydroxyvitamin (25(OH)D)<50 nmol/l) 3rd-trimester living (n 305), correlation between 25(OH)D offspring at birth 278). Demographic questionnaire data were used explore deficiency. Median concentration serum third trimester 46·0 nmol/l (1st-3rd quartiles: 30·5-68·5), representing a 53·4 % levels umbilcal cord blood (median: 50·0 nmol/l; 1st-3rd 31·0-76·6) strongly correlated mothers' (Spearman's ρ=0·79, P<0·001). Multivariable logistic regression analysis showed that significant centre study, country origin, season delivery supplement intake. Near-term BMI, skin colour, use sunscreen education, although each not individually significant, collectively improved ability model explain status. Low common this sample newborns' blood. intake most actionable determinant status, suggesting supplementation should receive more attention clinical practice.