Soya proteinβ-conglycinin ameliorates fatty liver and obesity in diet-induced obese mice through the down-regulation of PPARγ

• DOI: 10.1017/s0007114518000739
• Publication Date: 2018-05-17T09:17:34Z
• Authors: Dongyang Li; Reina Ikaga; Tomomi Yamazaki
• Keywords: Diet-induced obese

Abstract Diets high in fat can result obesity and non-alcoholic fatty liver disease (NAFLD). The improvement of NAFLD is an important issue. β -Conglycinin, one the soya proteins, known to prevent hyperlipidaemia, NAFLD. Therefore, we aimed investigate effects -conglycinin on high-fat (HF) diet-induced obese (DIO) mice clarify mechanism underlying these white adipose tissue (WAT). DIO male ddY were divided into six groups: HF, medium-fat (MF) low-fat (LF) groups fed casein, MF LF all which casein was replaced by -conglycinin. A period 5 weeks later, -conglycinin-supplemented group resulted lower body weight, relative weight subcutaneous WAT, hepatic TAG content ( P =0·001). Furthermore, suppressed expression Pparγ2 HF dietary group, sterol regulatory element-binding protein-1c target genes. expressions inflammation-related genes significantly low epididymal WAT from compared with those group. Moreover, Pparγ1 mRNA but not WAT. concentrations insulin leptin serum In conclusion, effectively improved mice, it appears be a promising protein for amelioration obesity.