Congenital transmission of Mexican strains of Trypanosoma cruzi TcIa: interaction between parasite and human placental explants

• DOI: 10.1017/s0031182021002018
• Publication Date: 2021-11-24T01:59:16Z
• Authors: Cecilia Gomes Bar...; César Gómez-Herná...; Marcos Vinícius d...; Karine Rezende-Ol...; Paula Tatiana Mut...; Ana Carolina Mora...; Chamberttan Souza...; Fernanda Rodrigue...; Tamires Marielem ...; Ingrid Ketlen Per...; Lorena Kelly Alve...; Carlo José Freire...; Juliana Reis Machado; Eloisa Amália Vie...; Virmondes Rodrigues; Luís Eduardo Ramirez
• Keywords: Infectivity; Chagas Disease; Syncytiotrophoblasts; Ex vivo

Abstract Congenital transmission of Chagas disease plays an important role in endemic countries because it is not a diagnosis that encountered frequently prenatal care. Due to limited information regarding congenital Trypanosoma cruzi Mexico, the present study aimed investigate protozoan infectivity and modulation immune responses human placental explants infected with T. Ia Mexican strains. The Inc-5 strain showed increased modulated IL-1 β , IL-10 TLR-4, decreasing their expression after 24 h infection. Both strains (Inc-5 Ninoa) stimulated production TNF- α decreased IL-6 levels 96 An detachment syncytiotrophoblast caused by infection was observed In this study, ex vivo villi performed better understand interactions involving parasitic tissue. It concluded TcIa parasitism tissue, innate system placenta, cause intense syncytiotrophoblast, fact may be more associated abortion premature birth events than itself, justifying low rate mechanism genotype.