The pattern of function-related regional cerebral blood flow investigated by single photon emission tomography with99mTc-HMPAO in patients with presenile Alzheimer's disease and Korsakoff's psychosis

• DOI: 10.1017/s0033291700005560
• Publication Date: 2009-07-09T14:24:39Z
• Authors: R. Hunter; R. McLuskie; D. Wyper; J. Patterson; J. E. Christie; D. N. Brooks; J. McCulloch; G. Fink; G. M. Goodwin
• Keywords: Frontal lobe; Temporal cortex

SYNOPSIS Single photon emission tomography (SPET) with the lipophilic blood flow marker 99m Tc-hexamethyl propyleneamine oxime ( Tc-HMPAO) has been used to determine regional uptake of radiolabel into brain regions patients presenile Alzheimer's disease and Korsakoff's psychosis, age-matched controls. Using occipital cortical as reference area, pattern relative cerebral (rCBF) was determined in other areas basal ganglia. In disease, reduction rCBF occurred most strikingly posterior temporal parietal areas. By contrast, maintained, although there a trend reduced tracer These impairments were correlated neuropsychological function. left particular showed be strongly aspects cognitive however, impaired frontal performance on tests memory orientation. The findings show quantitative parallels those from studies using Positron Emission Tomography (PET), extend our understanding relationship between cognition function dementia. psychosis offer first direct evidence linking lobe dysfunction impairment seen disorder.