Relationship between cognitive functioning and 6-month clinical and functional outcome in patients with first manic episode bipolar I disorder

• DOI: 10.1017/s0033291710001613
• Publication Date: 2010-09-01T14:49:40Z
• Authors: I. J. Torres; C. M. DeFreitas; V. G. DeFreitas; D. J. Bond; M. Kunz; W. G. Honer; R. W. Lam; L. N. Yatham
• Keywords: Adult; Male; Memory Disorders; Bipolar Disorder; Neuropsychological Tests; Prognosis; 3. Good health; Executive Function; 03 medical and health sciences; 0302 clinical medicine; Activities of Daily Living; Humans; Female; Longitudinal Studies; Cognition Disorders

Background Although cognitive deficits in bipolar disorder have been associated with diminished functional outcome, this relationship has studied primarily through cross-sectional designs, and not patients early the course of illness. The purpose study was to evaluate impact functioning on longitudinal 6-month clinical outcome recently diagnosed clinically stable disorder. Method A total 53 DSM-IV type I were assessed within 3 months their first manic episode using a neuropsychological battery measuring verbal/pre-morbid intellectual functioning, learning/memory, spatial/non-verbal reasoning, attention/processing speed executive function. Functional at baseline 6 Multidimensional Scale Independent Functioning (MSIF) Global Assessment (GAF). Clinical symptom ratings by monitoring onset new mood episodes. Results Memory, particularly verbal robustly MSIF, even after partialling out influence symptoms substance abuse co-morbidity. Depression months, but variables, GAF scores. Cognitive outcome. Conclusions Memory These data further support distinction between emphasize need for identification of, development treatments for, impairments