Trajectories of symptom dimensions in short-term response to antipsychotic treatment in patients with a first episode of non-affective psychosis

• DOI: 10.1017/s0033291713000330
• Publication Date: 2013-03-06T11:10:24Z
• Authors: J. M. Pelayo-Terán; F. J. Diaz; R. Pérez-Iglesias; P. Suárez-Pinilla; R. Tabarés-Seisdedos; J. de León; B. Crespo-Facorro
• Keywords: dup; Ziprasidone

Background Trajectory patterns of positive, disorganized and negative dimension symptoms during antipsychotic treatment in drug-naive patients with first-episode psychosis have yet to be examined by using naturalistic data. Method This pragmatic clinical trial randomized 161 a first episode olanzapine, risperidone or haloperidol. Patients were assessed the Scale for Assessment Negative Symptoms (SANS) Positive (SAPS) at baseline end weeks 1, 2, 3, 4 6 treatment. Censored normal models response trajectories developed three dimensions SAPS-SANS scores (positive, negative) order identify different trajectories. Diagnosis, cannabis use, duration untreated (DUP), smoking class as possible predictive variables. Results classified five groups according positive dimension, dimension. Longer DUPs use associated higher poorer responses Cannabis was Only schizophrenia diagnosis Conclusions Our results illustrate heterogeneity short-term antipsychotics highlight markedly dimensions. DUP, appeared prognostic value predicting implications each