Dynamic interplay between life events and course of psychotic disorders: 10-year longitudinal study following first admission

• DOI: 10.1017/s0033291720003992
• Publication Date: 2020-11-04T08:34:57Z
• Authors: Kayla R. Donaldson; Katherine G. Jonas; Yuan Tian; Emmett M. Larsen; Daniel N. Klein; Aprajita Mohanty; Evelyn J. Bromet; Roman Kotov
• Keywords: Depression

Abstract Background Life events (LEs) are a risk factor for first onset and relapse of psychotic disorders. However, the impact LEs on specific symptoms – namely reality distortion, disorganization, negative symptoms, depression, mania remains unclear. Moreover, differential effects v. positive poorly understood. Methods The present study utilizes an epidemiologic cohort patients ( N = 428) ascertained at first-admission psychosis followed decade thereafter. Symptoms were assessed 6-, 24-, 48-, 120-month follow-ups. Results We examined symptom change within-person found that in previous 6 months predicted increase distortion β 0.07), disorganized manic 0.08), depressive 0.06), decrease −0.08). Conversely, fewer −0.04), −0.13) unrelated to mood symptoms. A between-person approach same hypotheses confirmed all while only In contrast, rarely future LEs. Conclusions These findings confirm have effect thus contribute burden That suggest least two different mechanisms underlying relationship between Our underscore need increased monitoring following LEs, as may worsen during time.