Modelling mass drug administration strategies for reducing scabies burden in Monrovia, Liberia

• DOI: 10.1017/s0950268823001310
• Publication Date: 2023-08-18T09:57:04Z
• Authors: Nefel Tellioglu; Rebecca H. Chisholm; Patricia Therese ...; Shelui Collinson; Joseph Timothy; Karsor Kollie; Samuel Zayzay; Angela Devine; Jodie McVernon; Michael Marks; Nicholas Geard
• Keywords: Mass drug administration

Abstract Scabies is a parasitic infestation with high global burden. Mass drug administrations (MDAs) are recommended for communities scabies prevalence of >10%. Quantitative analyses needed to demonstrate the likely effectiveness MDA recommendations. In this study, we developed an agent-based model transmission calibrated demographic and epidemiological data from Monrovia. We used compare scenarios achieving elimination reducing burden, as measured by time until recrudescence following delivery disability-adjusted-life-years (DALYs) averted. Our showed that three rounds delivered at six-month intervals reaching 80% population could reduce below 2% years final round, before recrudescence. When MDAs were followed increased treatment uptake, was maintained indefinitely. Increasing number coverage probability DALYs results suggest acute reduction can support transition improved access. This study demonstrates how modelling be estimate expected impact projecting future dynamics health gains under alternative scenarios.