Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo

• DOI: 10.1021/acs.biochem.0c00658
• Publication Date: 2020-12-05T02:27:18Z
• Authors: Yuchen Zhou; Steven Ramsey; Davide Provasi; Amal El Daibani; Kevin Appourchaux; Soumen Chakraborty; Abhijeet Kapoor; Tao Che; Susruta Majumdar; Marta Filizola
• Keywords: Natural product

Pain management devoid of serious opioid adverse effects is still far from reach despite vigorous research and development efforts. Alternatives to classical opioids have been sought for years, mounting reports individuals finding pain relief with kratom recently intensified on this natural product. Although the composition complex, pharmacological characterization its most abundant alkaloids has drawn attention three molecules in particular, owing their demonstrated antinociceptive activity limited side