Annexins A1 and A2 Accumulate and Are Immobilized at Cross-Linked Membrane–Membrane Interfaces

• DOI: 10.1021/acs.biochem.1c00126
• Publication Date: 2021-04-16T20:42:55Z
• Authors: Martin Berg Klenow; Christoffer Iversen; Frederik Wendelbo...; Anna Mularski; Anne Sofie Busk H...; Catarina Dias; Jesper Nylandsted; Adam Cohen Simonsen
• Keywords: 0301 basic medicine; 571; plasma membrane repair; Time-lapse measurements show; Immunology; ANXA 1; Biophysics; Marine Biology; Phosphatidylserines; membrane cross-linking; Biochemistry; ANXA 2 function; annexin; 03 medical and health sciences; Humans; GUV; Molecular Biology; Annexin A2; Unilamellar Liposomes; Annexin A1; membrane interface; Cell Membrane; giant unilamellar vesicles; PMR; Cell Biology; confocal microscopy images; PS lipids display; Cross-Linking Reagents; Immobilized Proteins; Physical Sciences not elsewhere classified; ANXA 2-induced membrane cross-linking; Fluorescence Recovery After Photobleaching

Rapid membrane repair is required to ensure cell survival after rupture of the plasma membrane. The annexin family proteins involved in (PMR) and activated by influx Ca