Enhanced DNA Binding and Photocleavage Abilities of β-Cyclodextrin Appended Ru(II) Complex through Supramolecular Strategy

• DOI: 10.1021/acs.bioconjchem.8b00191
• Publication Date: 2018-05-29T19:58:26Z
• Authors: Ni Cheng; Yong Chen; Jie Yu; Jing-jing Li; Yu Liu
• Keywords: Adamantane

Photosensitizers with high photocleavage ability are urgently needed to improve photodynamic therapy efficacy. Herein, a supramolecular complex was constructed through host–guest self-assembly using hexa-β-CD-appended ruthenium polypyridyl (6CD-Ru) and adamantane-modified anthracene (ADA-AN) in water. The targeted DNA-intercalation of peripheral anthracenes can remarkably enhance antitumor activity the irradiated visible light.