Two-Dimensional Borocarbonitride Nanosheet-Engineered Hydrogel as an All-In-One Platform for Melanoma Therapy and Skin Regeneration

• DOI: 10.1021/acs.chemmater.2c01457
• Publication Date: 2022-07-01T15:24:20Z
• Authors: Cancan Zhao; Jianyu Wan; Liangzhu Zhang; Chen Zhang; Jiemin Wang; Kaili Lin; Xudong Wang
• Keywords: Biocompatibility; Light therapy; Photothermal effect

The postoperative tumor recurrence and repairing skin defects in clinical melanoma therapy remain challenging. Recent years have seen the development of visible-to-near-infrared (NIR) light for or tissue regeneration. For solving integrated issue treatment wounds repair, a gentle efficient strategy is essential to utilize multifunction light. Here, we presented new light-mediation concept reported light-responsive intelligent hydrogel system by introducing two-dimensional (2D) borocarbonitride (BCN) nanosheets into methacrylated hyaluronic acid (HA) matrix (HA@BCN). was skillfully fabricated under activation blue exhibited excellent biocompatibility, mechanical robustness, biodegradability, then, powerful cutaneous wound healing NIR irradiation performed. Based on this result, multifunctional hydrogels could be triggered (0.35 W/cm2) killing cells, at least an 80% mortality rate 10 min. Subsequently, HA@BCN release more boron moieties as growth promoter moderate irradiation, which largely accelerated healing. Therefore, our discovery light-mediated 2D nanomaterial-functionalized versatile photothermal therapy.