Ambient Air Pollutants and Incident Microvascular Disease: A Cohort Study

• DOI: 10.1021/acs.est.2c00898
• Publication Date: 2022-05-26T14:48:42Z
• Authors: Fu-Rong Li; Bin Zhu; Jian Liao; Zhiyuan Cheng; Cheng Jin; Chunbao Mo; Fengchao Liang
• Keywords: Interquartile range

Little is known about the links between long-term exposure to air pollution and risk of incident microvascular disease (retinopathy, peripheral neuropathy, chronic kidney disease). This study included 396 014 UK residents free macrovascular at baseline. Annual means PM2.5, PM2.5–10, PM10, NO2, NOx were assessed by land use regression models for each participant. A weighted score was generated from PM10 NOx. Cox proportional hazards used estimate hazard ratios (HRs) 95% confidence intervals (CIs). During a median follow-up 11.7 years, 14 327 composite occurred. While none pollutants showed any statistically significant association with retinopathy, all linked neuropathy disease. The adjusted-HRs (95% CIs) interquartile range increase in 1.07 (1.05, 1.09), 1.01 (0.94, 1.07), 1.13 (1.08, 1.19), 1.10) overall disease, respectively. In conclusion, associated higher risks among general population.