Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters

• DOI: 10.1021/acs.est.3c10314
• Publication Date: 2024-07-25T23:43:56Z
• Authors: Haotian Wu; Vrinda Kalia; Katherine E. Manz; Lawrence Chillrud; Nathalie Hoffmann...; Gabriela L. Jackson; Christian K. Dye; Raoul Orvieto; Adva Aizer; Hagai Levine; Marianthi-Anna Ki...; Kurt D. Pennell; Andrea A. Baccarelli; Ronit Machtinger
• Keywords: Exposome; Semen Analysis

Indicators of male fertility are in decline globally, but the underlying causes, including role environmental exposures, unclear. This study aimed to examine organic chemical pollutants seminal plasma, both known priority chemicals and less studied chemicals, identify uncharacterized reproductive toxicants. Semen samples were collected from 100 individuals assessed for sperm concentration, percent motility, total motile sperm. Targeted nontargeted pollutant exposures measured plasma using gas chromatography, which showed widespread detection across all exposure classes. We used principal component pursuit (PCP) on our targeted panel derived one (driven by etriadizole) associated with (p < 0.001) concentration = 0.03). was confirmed exposome-wide association models individual where etriadizole negatively (FDR q 0.01) (q 0.07). Using PCP 814 spectral peaks identified a that 0.001). Bayesian kernel machine regression driver this association, analytically be N-nitrosodiethylamine. These findings promising consistent experimental evidence showing etridiazole N-nitrosodiethylamine may