Medium-Chain Chlorinated Paraffins Trigger Thyroid Hormone Synthesis and Interfere with Mitochondrial Function in the Thyroid Gland

• DOI: 10.1021/acs.est.4c01341
• Publication Date: 2024-08-22T21:53:13Z
• Authors: Lin Cheng; Shuangshuang Chen; Yun Luo; Yuan Gao; Yan Ren; Haijun Zhang; Jiping Chen; Ningbo Geng
• Keywords: Chlorinated paraffins

Medium-chain chlorinated paraffins (MCCPs, C14–C17) are frequently detected in diverse environmental media. It has been proposed to be listed Annex A of the Convention on Persistent Organic Pollutants 2023. Although MCCPs a crucial health concern, their toxicity remains unclear. This study investigated toxic effects (0.1–50 mg/kg body weight/day) thyroid gland female Sprague–Dawley rats and characterized potential pathways via transcriptomics metabolomics approaches. exposure caused histopathological changes endoplasmic reticula mitochondria follicular cells at dose 50 bw/d increased serum thyrotropin-releasing hormone, thyroid-stimulating hormones, thyroxine when exposed higher MCCPs. Transcriptomic analysis indicated excessive expression key genes related hormone synthesis induced by Integrating dual-omics revealed mitochondrial dysfunction mediating fatty acid oxidation, Kreb's cycle, oxidative phosphorylation. Significant metabolic might linked characteristics chlorine content triggering interfering with function, which can provide new insights into modes action mechanism-based risk assessment