Occurrence and Distribution of Photoinitiator Additives in Paired Maternal and Cord Plasma in a South China Population

• DOI: 10.1021/acs.est.9b03127
• Publication Date: 2019-08-14T19:37:06Z
• Authors: Juan Li; James C. W. Lam; Wenzheng Li; Bibai Du; Hui Chen; Lixi Zeng
• Keywords: Cord blood

Photoinitiators (PIs) are widely used in industrial polymerization and have been detected as emerging contaminants environmental matrixes. It has reported that humans exposed to PIs, but the maternal-fetal transmission of PIs not documented. In this study, we analyzed 21 (9 benzophenones, BZPs; 8 amine co-initiators, ACIs; 4 thioxanthones, TXs) matched maternal-cord plasma samples from 49 pregnant women South China. Sixteen target were found maternal at concentrations ∑PIs (sum PIs) 303 3500 pg/mL. Meanwhile, 12 cord with 104 988 The both dominated by BZPs, followed ACIs TXs. Different groups showed structure-dependent placental transfer efficiencies (PTEs). PTEs generally less than 100% for BZPs greater By further theoretical calculation, revealed critical structural features affect PTEs. This is first study investigate occurrence distribution paired plasma, it sheds light on potential mechanism transfer.