μ-MIP: Molecularly Imprinted Polymer-Modified Microelectrodes for the Ultrasensitive Quantification of GenX (HFPO-DA) in River Water

• DOI: 10.1021/acs.estlett.0c00341
• Publication Date: 2020-05-27T12:00:20Z
• Authors: Matthew W. Glasscott; Kathryn J. Vannoy; Rezvan Kazemi; Matthew D. Verber; Jeffrey E. Dick
• Keywords: Molecularly imprinted polymer; Molecular imprinting

Per- and polyfluoroalkyl substances (PFAS) are emerging as a hazardous class of environmental micropollutant, robust, sensitive, inexpensive sensing modalities needed to detect the earliest onset contamination surface water. Here, we present molecularly imprinted polymer (MIP)-modified microelectrode (r = 6.25 μm) sensor for quantification pervasive PFAS, GenX (HFPO-DA), in water obtained from Haw River North Carolina. A 20 nm film o-phenylenediamine was electropolymerized presence generate templated adjacent electrode with subsequent solvent extraction resulting GenX-specific recognition sites. The oxidation ferrocene methanol observed function concentration, current decreased linearly concentration GenX. linear dynamic range 1–5000 pM limit detection 250 fM excellent selectivity against interferents, such humic acid perfluorooctanesulfonate, achieved. use oxygen reduction an additional ambient mechanism amenability microelectrodes relatively resistive matrices demonstrated extend applicability MIP-modified waterways deployable sensors.