Impact of Secondary Organic Aerosol on the Respiratory Viral Infection in Vitro

• DOI: 10.1021/acs.estlett.4c00217
• Publication Date: 2024-05-14T19:32:00Z
• Authors: Shunyao Wang; Xi Zhang; Kaisen Lin; Guanwen HUANG; Yue Zhao; Hin Chu; Arthur W.H. Chan

Inhalation of viable airborne pathogens often leads to respiratory infections. Among the different factors that affect survival pathogens, specific aerosol composition, such as secondary organic (SOA), may impact severity infection by stimulating host cell apoptotic responses. Here, we studied in vitro effects SOA (biogenic and anthropogenic) on human influenza A virus (H1N1). Viral gene copies bronchial epithelial line (BEAS-2B) fetal lung fibroflast (MRC-5) treated with were measured be significantly from control group. maximum enhancement 56%, 77%, 45% H1N1 replication was observed for BEAS-2B cells exposed doses α-pinene SOA, toluene naphthalene respectively. various precursors impacted viral differently, indicating importance emission source composition. For cells, anthropogenic (toluene naphthalene) suppressed at low (1 μg mL–1 5 mL–1) enhanced higher doses. Interplay among source, oxidative stress, apoptosis, highlights having air pollution mitigation strategies out a public health perspective.