Cinnamic Acid: A Low-Toxicity Natural Bidentate Ligand for Uranium Decorporation

• DOI: 10.1021/acs.inorgchem.4c00610
• Publication Date: 2024-04-10T15:15:55Z
• Authors: Yawen Liu; Bin Zhao; Pan He; Zeru Wang; Kui Tang; Zhiwei Mou; Yi Tan; Linzhen Wu; Guangyuan Chen; Xiaoan Li; Lin Zhu; Tao Duan
• Keywords: Uranyl; Uranyl nitrate; Cinnamic acid

Uranium accumulation in the kidneys and bones following internal contamination results severe damage, emphasizing pressing need for discovery of actinide decorporation agents with efficient removal uranium low toxicity. In this work, cinnamic acid (3-phenyl-2-propenoic acid, CD), a natural aromatic carboxylic is investigated as potential ligand. CD demonstrates markedly lower cytotoxicity than that diethylenetriaminepentaacetic (DTPA), an agent approved by FDA, effectively removes approximately 44.5% uranyl from NRK-52E cells. More importantly, prompt administration solution remove 48.2 27.3% femurs mice, respectively. Assessments serum renal function reveal to ameliorate uranyl-induced injury. Furthermore, single crystal compound (C