MOF-Supported Diphosphine Ligands for Iridium-Catalyzed C–H Borylation of Arenes

• DOI: 10.1021/acs.inorgchem.5c00523
• Publication Date: 2025-04-02T06:12:02Z
• Authors: Jordon S. Hilliard; Daniel J. Murray; Ankita Saha; Joshua E. Goldberger; Casey R. Wade
• Keywords: Borylation

Postsynthetic methods have been used to immobilize a carboxylate-functionalized diphosphine ligand, N,N-bis[(diphenylphosphino)methyl]glycinate (dppmg), in different metal-organic framework (MOF) supports. H(dppmg) reacts quantitatively with Zn-OH groups MFU-4l-OH (1) provide solid-state ligands (1-H-x) controllable loadings. metalation [Ir(OMe)(cod)]2 (cod = 1,5-cyclooctadiene) generates heterogeneous precatalysts (1-Ir-x) that show excellent activity toward C-H borylation of arenes. This is dependent on both the catalyst site density and initial concentration borylating reagent. Homogeneous catalysts supported by analogous exhibit low catalytic activity, demonstrating beneficial role isolation. Immobilization dppmg-Ir at Zr-based nodes MOF-808 (2-P-Ir) NU-1000 (3-P-Ir) results materials relatively poor toluene, revealing importance MOF support design.