Consumption of Interesterified Medium- and Long-Chain Triacylglycerols Improves Lipid Metabolism and Reduces Inflammation in High-Fat Diet-Induced Obese Rats

• DOI: 10.1021/acs.jafc.0c03103
• Publication Date: 2020-07-09T14:19:38Z
• Authors: Ying-Xue Du; Sun-Ni Chen; Hong-Lin Zhu; Xian Niu; Jing Li; Ya-Wei Fan; Ze-Yuan Deng
• Keywords: Male; 2. Zero hunger; 0303 health sciences; Esterification; Tumor Necrosis Factor-alpha; Adipose Tissue, White; Diet, High-Fat; Lipid Metabolism; Rats; 03 medical and health sciences; Cholesterol; Liver; Animals; Humans; Rapeseed Oil; Obesity; Chemokine CCL2; Triglycerides

Medium- and long-chain triacylglycerols (MLCTs) were synthesized from rapeseed oil (RO), one kind of commonly used edible (TGs), then delivered to high-fat diet (HFD)-induced obese rats. Compared with RO, MLCT consumption exhibited more potent effects on reducing body tissue weight gains, plasma TG, total cholesterol (TC) levels improving hepatic TC, fatty acid synthase, acetyl-CoA carboxylase, lipoprteinlipase contents. Meanwhile, lower amounts tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1, endotoxin in plasma, interleukin-6 TNF-α, higher interleukin-10 both livers white adipose tissues detected MLCT-fed intake also remarkably suppressed the size adipocytes number macrophages. In conclusion, our study suggested that interesterified was efficacious lipid metabolism inflammation HFD-induced rats than RO.