Effects of Edible Oils with Different n-6/n-3 PUFA Ratios on Articular Cartilage Degeneration via Regulating the NF-κB Signaling Pathway

• DOI: 10.1021/acs.jafc.0c05240
• Publication Date: 2020-11-02T18:47:25Z
• Authors: Tianqi Zhang; Yufeng Dai; Lei Zhang; Yingying Tian; Zhuo Li; Jingfeng Wang
• Keywords: Cartilage, Articular; 0303 health sciences; NF-kappa B; 3. Good health; Mice, Inbred C57BL; Mice; 03 medical and health sciences; Fatty Acids, Omega-6; Fatty Acids, Omega-3; Animals; Humans; Plant Oils; Female; Cartilage Diseases

Osteoarthritis (OA), a common chronic disease, is characterized by articular cartilage degeneration and inflammation. Recent studies report that n-3 polyunsaturated fatty acids (PUFAs) exhibit protective effects against OA, while n-6 PUFAs are more likely to damage cartilage. However, the of edible oils with different n-6/n-3 PUFA ratios on OA rarely reported. This study investigates effect linseed oil (LO), soybean (SO), peanut (PO) changes in mice joints following destabilization medial meniscus. We determined LO, SO, PO used this experiment be 1:3.85, 9.15:1, 372.73:1, respectively. After 12 weeks LO or SO feeding, showed increased thickness decreased TNF-α both serum cartilage, whereas no improvement was found group. may due fact optimized acid composition further demonstrated activated GPR120 attenuated EP4, which followed inhibition NFκB pathway its downstream matrix-degrading enzymes: MMP13 ADAMTS5. In conclusion, low retard progression via inhibiting pathway. provides dietary guidance for patients.